What you’ll learn
- Follow a compound through the pathway. Understand Phase I transformation, Phase II conjugation, and why production and clearance must be interpreted together.
- Interpret the major clearance systems. Examine glutathionation, glucuronidation, methylation, acetylation, and sulfation in context.
- Distinguish different types of variation. Understand why GST copy-number findings require different interpretation from reduced-function SNPs.
- Assess the buffer. Evaluate glutathione capacity alongside CYP1B1, COMT, GST, and the patient’s oxidative and environmental load.
- Build an individualized clearance picture. Use the tap, valve, and buffer framework to guide the depth of investigation and supportive care.
See the whole clearance picture.
Cost: $299
Included: A physical Quicksilver kit curated for this course
Format: Online and self-paced
Start with: Foundations of Functional Genomics, free
Work through the production-and-clearance framework, apply it to clinical cases, and check your understanding through a case-based assessment. The course includes Phase I and Phase II pathway tools, GST interpretation guidance, the Phase II Big Five, and the tap, valve, and buffer framework.
Connect clearance with the pathways around it.
Detoxification does not operate in isolation. Continue through methylation, neurochemistry, and vascular health to understand how clearance capacity intersects with hormone metabolism, inflammation resolution, stress physiology, and cumulative vascular load.
The Clinical Genomics Certification is $1,999 and includes all eight modules, a combined Quicksilver kit, practice implementation support, and three months of educational chatbot access.
