{"product_id":"kpv","title":"KPV: Anti-Inflammatory \u0026 Gut-Targeted Peptide","description":"\u003ch3 dir=\"ltr\"\u003eContext-Dependent Inflammation Control via PepT1 Mucosal Targeting\u003cbr\u003e\n\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003eKPV (Lysine–Proline–Valine) is a naturally occurring tripeptide derived from the C-terminal sequence of α-melanocyte-stimulating hormone (α-MSH). It retains α-MSH’s anti-inflammatory and immunomodulatory properties without its pigmentation side effects.\u003cbr\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003eKPV’s defining feature is context-dependent activity: it preferentially enters inflamed tissue via the PepT1 transporter while remaining largely inert in healthy tissue. This makes oral liposomal delivery mechanistically optimal for GI inflammation — the oral route delivers intact peptide directly to inflamed intestinal mucosa where PepT1 is upregulated.\u003cbr\u003e\u003c\/p\u003e\n\u003cp class=\"fs-gold\" dir=\"ltr\"\u003e\u003cspan\u003eEvidence Tier: C (Emerging) — robust preclinical data across multiple colitis models; strong mechanistic plausibility via PepT1\/NF-κB pathway; no published human efficacy data. \u003c\/span\u003e\u003c\/p\u003e\n","brand":"Cell Signaling Institute","offers":[{"title":"Default Title","offer_id":47237820154005,"sku":null,"price":199.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0772\/7359\/6053\/files\/pdp_logo.png?v=1775623177","url":"https:\/\/cellsignalinginstitute.com\/products\/kpv","provider":"Cell Signaling Institute","version":"1.0","type":"link"}